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NVP-231 - CAS# 362003-83-6 ticancer activities Formula: C35H46O20

SKU: 17482620749

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Description

Formula: C35H46O20

acting as a potent PKC activator

Jończyk J

Glycogen synthase kinase-3β inhibition ameliorates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice

144(1):163-72

NVP-231 - CAS# 362003-83-6 ticancer activities Formula: C35H46O20NVP 231, CAS No. 362003 83 6, is a potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK. NVP 231 is active in the low nanomolar range on purified as well as cellular CerK and abrogates phosphorylation of ceramide, resulting in decreased endogenous C1P levels. When combined with another ceramide metabolizing inhibitor, such as tamoxifen, NVP 231 synergistically increased ceramide levels and reduced

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