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InChi: InChI=1S/C15H11FN2S/c16-12-6-8-13(9-7-12)17-15-18-14(10-19-15)11-4-2-1-3-5-11/h1-10H
tight binding inhibitor of human inducible nitric- oxide synthase (iNOS)
cholinesterases or carnitine acetyltransferase at concentrations which inhibits ChA
Pre-treatment with 1 μM Lomerizine significantly reduces acute death of motor neurons in spinal cord-DRG cultures exposed to 50 μM glutamate
InChi: InChI=1S/C18H21NS
Emetine dihydrochloride hydrate 12582 InChi: InChI=1S/C15H11FN2S/c16-12-6-8-13(9-7-12)17-15-18-14(10-19-15)11-4-2-1-3-5-11/h1-10HEmetine dihydrochloride hydrate is an anti protozoal drug previously used for intestinal and tissue amoebiasis. Emetine dihydrochloride hydrate is reported to have an IC50 value of 1 nM on the drug sensitive 3D7 P. falciparum parasite strains. Dose response curves are determined for both drugs using K1 resistant isolates and IC50 values of 472. 1 nM and 2. 60. 41 nM established for emetine dihydrochloride hydrate and DHA, respectively. After the
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