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in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction
JW74 also enhances differentiation of OS cell lines
Formula: C16H22Cl2N2O5S
InChi: InChI=1S/C33H48N4O6S/c1-22-29(44-21-35-22)24-16-14-23(15-17-24)19-34-31(42)26-18-25(38)20-37(26)32(43)30(33(2
It can inhibit oncogenic RAS signaling and suppress in vitro and in vivo proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS
VU0364770 hydrochloride Size:Contact [email protected] for quotation in human lung adenocarcinoma A549VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1. 1 M at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17. 9 M and PAM activity at mGlu6 with a potency of 6. 8 M. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8. 5 and 0. 72 M for human MAO A