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Altiratinib also inhibits FLT3-ITD mutant MV-4-11 cell proliferation with an IC50 of 12 nM
is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM)
1192189-70-0 (acetate)
Smiles: CN1CCN(CC1)C1=CC(OC)=C(C=C1)NC1=NC(OC2=CC(=CC=C2)NC(=O)C=C)=C(Cl)C=N1
1579991-63-1 (free base)
c-di-AMP e metabolite Omeprazole sulfone Altiratinib also inhibits FLT3-ITD mutantc di AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3 IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c di AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram positive bacteria, and also regulates host immune response. c di AMP (Cyclic diadenylate) acts as a