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cardiac hypertrophy
5-25 mg/Kg to a panel of human-patient-derived and cell-line-derived xenograft (PDX and CDX
3 mg/kg) shows efficacy in the rat CIA model
Mohamed A Kandil
8(39):65313-65328
Capsazepine - CAS# 138977-28-3 116VP-QAV-572 cardiac hypertrophyCapsazepine is TRPM8 a antagonist. Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel. It is therefore considered to be a capsaicin antagonist. The TRPV1 channel functions as a pain and temperature sensor in mammalians. Capsazepine blocks only the activation of TRPV1 channels by chemicals but not by other painful stimuli, like heat. Depending on the
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