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8(5):651-681
CAS Number: 1286739-19-2
InChi: InChI=1S/C24H19F2N3O4S/c25-16-6-5-13-15(20(16)26)12-34-18-4-2-1-3-14(18)21(13)29-19-11-33-10-9-27(19)24(32)22-23(31)17(30)7-8-28(22)29/h1-8
11aH-cyclopenta[a]phenanthren-1-yl furan-2-carboxylate
2018 Aug 28
PKI-179 - CAS# 1197160-28-3 and Peptide TFA 8(5):651-681PKI 179 is a potent and orally active dual PI3K mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0. 42 nM for PI3K , PI3K , PI3K , PI3K and mTOR, respectively. PKI 179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI 179 shows anti tumor activity in vivo. Product information CAS Number: 1197160 28 3 Molecular Weight: 488. 54 Formula: C25H28N8O3 Chemical Name: 1 {4 [4 (morpholin 4 yl) 6 {3 oxa 8