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CAS Number: 1604810-83-4
PubMed Central PMCID: PMC3789222
Su-11274 treatment inhibits the growth of TPR-MET-transformed BaF3 cells in a dose-dependent manner with IC50 of < 3 μM in the absence of interleukin 3
6-fold resistant to crenolanib
Smiles: NS(=O)(=O)OC[C@H]1C[C@@H](NC2=CC=NC3=CC(=NN32)C2=CC(=CC=C2)SC(F)(F)F)[C@H](O)[C@@H]1O
KYA1797K - Wnt/β-catenin Inhibitor. CAS# 1956356-56-1 60166 CAS Number: 1604810-83-4KYA1797K, CAS No. 1956356 56 1, is a highly potent and selective Wnt catenin inhibitor with IC50 ~0. 75 M (TOPflash assay). It binds directly to the regulators of G protein signaling domain of axin, initiating catenin and Ras degradation through enhancement of the catenin destruction complex activating GSK3. KYA1797K can effectively suppress the growth of CRCs harboring APC and KRAS mutations, as shown by various in vitro studies and by in vivo
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