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OSI-027 was orally dosed to mice at 50-65 mg/kg once per day
2014 Jun 5
Collins MT
is a potent and selective breast cancer stem cell inhibitor with IC50 ~1
Derenzini E
Sephin1 Carbonate - PPP1R15A Protein Phosphatase Inhibitor. CAS# 951441-04-6 size:10mg solid OSI-027 was orally dosed toSephin1 Carbonate, CAS No. 951441 04 6, is a selective inhibitor of a holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo. Sephin1 selectively bound and inhibited the stress induced PPP1R15A, but not the related and constitutive PPP1R15B, to prolong the benefit of an adaptive phospho signaling pathway, protecting cells from otherwise lethal protein misfolding stress. In vivo, Sephin1 safely
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