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berghei) show that TCMDC-135051 has near-equipotent inhibition at these two orthologs
and tau in vitro
Smiles: CC(C)(C)[C@H](NC(=O)C1(F)CC1)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C=C1OCCOC1C=CC(=CC=1)C1OCCO1)C1SC=NC=1C
decreases MDM2
and is stable in plasma cross species
NVS-PAK1-C tinoic acid-d3 berghei) show that TCMDC-135051 hasNVS PAK1 C is a potent, ATP competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS PAK1 C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM). Product information CAS Number: 2250019 95 3 Molecular Weight: 465. 90 Formula: C22H23ClF3N5O Chemical Name: (3S) 3 {[13 chloro 2 (2,2 difluoroethyl) 6 fluoro 2,9
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