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PubMed Central PMCID: PMC3587237
2015 Jul 3
(2003) Nature
3-b]furan-4
PF-670462 2HCl
AZD3759 - CAS# 1626387-80-1 Catalog No.:M6469-10 PubMed Central PMCID: PMC3587237AZD3759, CAS No. 1626387 80 1, is also known as zorifertinib. It is an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR overexpressing cells. EGFR,
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