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CAS Number: 1446502-11-9
Cell-permeable
and exhibit significant efficacy in PTEN- and PI3K mutant xenograft models
GW-7647 (100 nM) causes a 24% reduction in AQP9 protein abundance in HepG2 cells
as well as TPM3-TRKA fusion KM-12 cells
Flavopiridol (Alvocidib) cadesine CAS Number: 1446502-11-9Alvocidib is a synthetic N methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin dependent kinases (CDKs) and by down regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity. Check for active clinical trials or closed clinical
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