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CAS Number: 1819363-80-8
Chem Pharm Bull (Tokyo)
RaH3 and RaH5
50(8):1876-85
(2012) Nature Methods 9(6)
MLN8237 (Alisertib) - Aurora A inhibitor. CAS# 1028486-01-2 60125 CAS Number: 1819363-80-8MLN8237 (Alisertib), CAS No. 1028486 01 2, is a highly potent and selective Aurora A inhibitor with an IC50 of 1. 2 nM, >200 fold selective towards structurally related Aurora B (IC50 of 396. 5 nM). It does not have any significant activity against 205 other kinases. MLN8237 treatment inhibits the phosphorylation of Aurora A in MM1. S and OPM1 cells, without affecting the Aurora B mediated histone H3 phosphorylation. MLN8237 significantly inhibits
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