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SNS-032 has low sensitivity to CDK1 and CDK4 with IC50 of 480 nM and 925 nM
InChi: InChI=1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10
validating IKK-2 as a potential anti-inflammatory drug target in vivo
Chemical Name: 1-(2-Ethylphenoxy)-3-[[(1S)-1
Pirovano G
MG-132 463518 SNS-032 has low sensitivity toMG132 is a specific, potent, reversible, and cell permeable proteasome inhibitor (Ki = 4 nM) . It reduces the degradation of ubiquitin conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c Jun N terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF B activation with an IC50 of 3 M and prevents secretase cleavage. MG 132
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