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CP-724714 potently reduces the EGF-induced autophosphorylation of the chimera containing the erbB2 kinase domain at a concentration as low as 50 nmol/L (IC50=32 nM) but is markedly less potent against EGFR
InChi: InChI=1S/C28H22F3N5O/c1-16-5-6-18(27(37)33-21-4-2-3-20(13-21)28(29
CAS Number: 917-13-5
is a cytotoxic agent that causes double-strand DNA breaks
NCCCNCCCCNCCCNC(=O)CC1=CC=CC2=CC=CC=C12
Diclofenac potassium - CAS# 15307-81-0 551 CP-724714 potently reduces the EGF-inducedDiclofenac potassium is a potent and nonselective anti inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1. 3 nM for human COX 1 and COX 2 in CHO cells, and 5. 1 and 0. 84 M for ovine COX 1 and COX 2, respectively. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade. Product information CAS Number: 15307 81 0 Molecular Weight: 334. 24 Formula: C14H10Cl2KNO2 Chemical Name:
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