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RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo
significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB (Compound 5e)
Alsterpaullone (Alp
13-pentaazacyclopentadecan-2-yl)acetic acid
PubMed PMID: 26561057
MK-5108 Size:Solid 2 mg RNAi-mediated ERK2 knockdown inhibits growthMK 5108, also known as VX689, is a novel small molecule with potent inhibitory activity against Aurora A kinase. MK 5108 specifically inhibited Aurora A kinase in a panel of protein kinase assays. MK 5108 also induced phosphorylated Histone H3 in skin and xenograft tumor tissues in a nude rat xenograft model. MK 5108 inhibited growth of human tumor cell lines in culture and in different xenograft models. MK 5108 is currently tested in clinical trials