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Pranlukast shows competitive antagonism against the LTC4- and LTD4-induced contractions of guinea pig trachea and lung parenchymal strips with a pA2 range of 7
KRIBB11 inhibits HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter
CAS Number: 69655-05-6
Inhibits MEK-1 and MEK-2 (IC50 values of 0
6-dihydroxy-4-methyl-2-oxabicyclo[2
TRAM 39 13081 Pranlukast shows competitive antagonism againstTRAM 39, 2 (2 chlorophenyl) 2, 2 diphenyl acetonitrile, is a potent, synthetic, selective inhibitor of intermediate conductance Ca2+ activated K+channels. TRAM 39 selectively block K Ca3 but do not inhibit other Ca2+ activated K+channels.[1,3] Intermediate conductance Ca2 activated K channels are the product of the IKCa1 genes and are important in regulating the membrane potential of colonic epithelial cells, and lymphocytes. The IKCa1 gene is also