PG106 yl-α-phenylnitrone 5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one

5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one

Initial studies have shown Ximelagatran to have good efficacy and safety in the prevention of venous thromboembolism after total knee or total hip replacement

which demonstrates both potential opportunity and possible challenges to therapeutic agonism

]octadeca-1(10)

282(7):4253-64

PG106 yl-α-phenylnitrone 5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-onePG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50=210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor. Product information CAS Number: 944111 22 2 Molecular Weight: 1008. 18 Formula: C51H69N13O9 Chemical Name: (3S,6S,9R,16S,24S) 6 (3 carbamimidamidopropyl) 2,5,8,11,15,18 hexahydroxy 16 [(Z) {1 hydroxy 2 [(Z) (1 hydroxyethylidene)amino]hexylidene}amino] 3 [(1H indol 3 yl)methyl] 9