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InChiKey: HIXSPVQXXDULHS-UHFFFAOYSA-N
3-b]quinoxaline
Ben-David U
PubMed Central PMCID: PMC4682489
Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models
(Z)-4-Hydroxytamoxifen - CRISPR Editing Enhancer. CAS# 68047-06-3 0124 InChiKey: HIXSPVQXXDULHS-UHFFFAOYSA-N(Z) 4 Hydroxytamoxifen (also called 4 OH TAM), CAS No. 68047 06 3, was previously characterized as an Estrogen Receptor antagonist and now found to improve genome editing specificity in CRISPR mediated gene editing. It can activate intein linked inactive Cas9, reducing off target. Such system has ~25 fold higher specificity than wtCas9. (Z) 4 Hydroxytamoxifen is a Tamoxifen metabolite to be used as chemotherapeutic agent. It exhibits greater potency