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Quebrachitol is a versatile building block in the construction of naturally occurring bioactive materials
Coinhibition of the deubiquitinating enzymes
potent and selective G-protein coupled receptor kinase 2 and 3 (GRK2/GRK3) inhibitor (IC50 values are 35 and 32 nM at GRK2 and GRK3 respectively)
PARP 1/2 inhibitor E-7449 may enhance the cytotoxicity of DNA-damaging agents and of radiotherapy
Following the IV dose in dogs
PLX-4720 - CAS# 918505-84-7 60209 Quebrachitol is a versatile buildingPLX 4720, CAS No. 918505 84 7, is a 7 azaindole derivative that inhibits B Raf(V600E) with an IC(50) of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX 4720 preferentially inhibits the active B Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele. Product information CAS Number: 918505 84 7
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