C-021 dihydrochloride dium formononetin-3'-sulfonate Dihydrexidine competes stereoselectively and potently

Dihydrexidine competes stereoselectively and potently for D1 binding sites in rat striatal membranes labeled with [3H]SCH23390 with an IC50 of about 10 nM compared to about 30 nM for the prototypical D1 agonist SKF38393

The first time point at which AZD9272 causes >90% MTEP-appropriate responding is at 30 minutes after dose

42(8):703-20

InChi: InChI=1S/C23H25ClN6O3/c1-25-22(31)16-5-3-4-6-18(16)27-21-17(24)14-26-23(29-21)28-19-8-7-15(13-20(19)32-2)30-9-11-33-12-10-30/h3-8

HIF-C2 is selective for the HIF-2 isoform and has no activity to antagonize HIF-1

C-021 dihydrochloride dium formononetin-3'-sulfonate Dihydrexidine competes stereoselectively and potentlyC 021 dihydrochloride is a potent CC chemokine receptor 4 (CCR4) antagonist. C 021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C 021 effectively prevents human CCL22 derived [35S]GTPS from binding to the receptor with an IC50 of 18 nM. Product information CAS Number: 1784252 84 1 Molecular Weight: 540. 57 Formula: C27H43Cl2N5O2 Chemical Name: (4E) 2 {[1,4' bipiperidin] 1' yl}