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thereby inhibits its DNA binding
2217/fmb-2018-0233
is a potent and selective Poly (ADP-Ribose) Polymerase (PARP) Inhibitor
and orally bioavailable inhibitor of gamma secretase with an IC50 of ~0
LAS-31180 is an inhibitor of phosphodiesterase 3
MPC-3100 224289 hydrochloride thereby inhibits its DNA bindingMPC 3100 is a purine based inhibitor of Hsp90 with IC50 value of 60nM . MPC 3100 targets the N terminal ATP binding site of Hsp90 and blocks the activity of ATPase. In the Her2 luciferase degradation assay, MPC 3100 reduces this client protein of Hsp90 with IC50 value of 60nM. In HCT 116 cell lines, MPC 3100 inhibits cell proliferation with IC50 value of 540nM. Besides that, MPC 3100 shows a broad spectrum anti proliferative activity against various
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