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108(18):7535-40
(2009) Mol Cancer Ther
Molecular Weight: 404
At 5 μM it directly inhibits DUB activity of USP9x
an enzyme responsible for the metabolic inactivation of enkephalins
Kartogenin (KGN) - Chondrogenesis Modulator. CAS# 4727-31-5 size:2mg solid 108(18):7535-40Kartogenin (KGN), CAS No. 4727 31 5, is a potent small molecule that can promote chondrocyte differentiation of human mesenchymal stem cells MSCs (EC50 = 100 nM). It was identified by an imaging based high throughput screening in human MSCs. KGN also shows chondro protective effects in vitro, and is efficacious in collagenase and surgery induced OA models in mice. MOA studies suggested that KGN binds to filamin A, disrupts its interaction with the
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