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It is being marketed by Boehringer Ingelheim and Lilly
CAS Number: 1228280-29-2
but only kill cells with MLL rearrangement
suggesting that the inhibitory activity is likely to be via a direct and fast mechanism
The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFκB signalling pathway
BMS-794833 - CAS# 1174046-72-0 itor 1 (R enantiomer hydrochloride) It is being marketed byBMS 794833 is a potent ATP competitive inhibitor of Met VEGFR2 with IC50 of 1. 7 nM 15 nM. BMS 794833 also inhibits Ron (Met family), Axl (phylogenetically related Axl Tyro3 Mer subfamily) and Flt 3 with IC50 values less than 3 nM. The compound was selective versus a panel of greater than 200 additional receptor tyrosine kinase (RTKs), non RTKs and serine threonine kinases based on biochemical or Ambit binding assays. Moreover, it inhibited the cell
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