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In MMTV-Wnt1 tumor models
Ledipasvir has GT1a and 1b EC50 values of 31 and 4 pM
JK184 was dosed orally 0
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation
Bissinger EM
G-749 - CAS# 1457983-28-6 Catalog No.:M6514-10 In MMTV-Wnt1 tumor modelsG 749, CAS No. 1457983 28 6, is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3 ITD, FLT3 D835Y, FLT3 ITD N676D, and FLT3 ITD F691L in cellular assays. G 749 retained its inhibitory potency in various drug resistance milieus such as patient plasma, FLT3 ligand surge, and stromal protection. Furthermore, it displayed potent antileukemic activity in bone marrow blasts from AML patients