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Ro 21-9738
51(4):413-21
ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30
It exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung
8(6):337-41
11-Beta-hydroxyandrostenedione orphenamide Ro 21-973811 Beta hydroxyandrostenedione (4 Androsten 11 ol 3,17 dione) is a steroid mainly found in the the adrenal origin (11 hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11 Beta hydroxyandrostenedione is a 11 hydroxysteroid dehydrogenase (11HSD) isozymes inhibitor. As 4 androstenedione increases, measuring plasma 11 Beta hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism. Product information
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