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IC50s = 75 nM and 3
in single agent and combination studies
δ and γ isoforms are 3 nM
Molecular Weight: 522
effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC50 0
IOX2 - HIF Prolyl-Hydroxylases (PHD2) Inhibitor. CAS# 931398-72-0 60109 IC50s = 75 nM andIOX2, CAS No. 931398 72 0, is a potent, selective and cell permeable inhibitor of hypoxia inducible factor 1 (HIF1) prolyl hydroxylase 2 (PHD2). It inhibits PHD2 with an IC50 ~21 nM, and exhibits over 100 fold selectivity against JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. IOX2 is active in cells, inhibiting HIF 1 hydroxylation in RCC4 cells at 50 M. Product information CAS Number: 931398 72 0 Molecular Weight: 352. 34 Formula: C19H16N2O5
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