RBPJ Inhibitor-1 365109 HCl Smiles: CC1=CC(=CC=N1)C1=NC=C(CNC(=O)C2=CC=C3C(=C2)NC2=CC=CC=C32)C=C1F

Smiles: CC1=CC(=CC=N1)C1=NC=C(CNC(=O)C2=CC=C3C(=C2)NC2=CC=CC=C32)C=C1F

as determined by loss of body weight and death of treated mice

3 nM in a radioactive enzyme assay and is over 100-fold selective for other histone methyltransferases/HMTs

3-benzodiazole

4'-dihydro-2'H-17

RBPJ Inhibitor-1 365109 HCl Smiles: CC1=CC(=CC=N1)C1=NC=C(CNC(=O)C2=CC=C3C(=C2)NC2=CC=CC=C32)C=C1FRBPJ Inhibitor 1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor 1 (RIN1) inhibits NOTCH dependent tumor cell proliferation. Product information CAS Number: 2682114 39 0 Molecular Weight: 311. 31 Formula: C17H14FN3O2 Synonym: RIN1 Chemical Name: 2 (2 fluorophenoxy) 4 (1 methyl 1H pyrazol 5 yl)benzamide Smiles: CN1N=CC=C1C1=CC(OC2=CC=CC=C2F)=C(C=C1)C(N)=O InChiKey: MFSSHRCJKRDIOL UHFFFAOYSA N