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[21] Phthalates have been implicated as endocrine disrupting chemicals, compounds that mimic the body's own hormones and can lead to dysregulation of the reproductive and neurologic systems as well as changes in metabolism and cell proliferation

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For example, aromatic anticonvulsants are metabolized by CYP (cytochrome P450 - phase I of drug metabolism) into arene-oxide metabolites, normally detoxified in the conjugation pathways (phase II of drug metabolism) into inactive metabolites by epoxide hydrolase or glutathione transferase